Acute severe ulcerative colitis consensus statements

http://www.ncbi.nlm.nih.gov/m/pubmed/27226344/

Open access review article on acute severe ulcerative colitis

http://www.ncbi.nlm.nih.gov/m/pubmed/27226344/

Knowledge and predictors of dysplasia surveillance performance in inflammatory bowel diseases in Australia - Gastrointestinal Endoscopy

Another paper on IBD and cancer. Surveillance colonoscopy knowledge is high in Australia. Gastroenterologists have higher knowledge scores than colorectal surgeons in this respect.

Knowledge and predictors of dysplasia surveillance performance in inflammatory bowel diseases in Australia - Gastrointestinal Endoscopy

#IBD #colitis #surveillance #colonoscopy

The learning curve: inter-observer and intra-observer agreement of endoscopic confocal laser endomicroscopy in the assessment of mucosal barrier defects - Gastrointestinal Endoscopy

The learning curve: inter-observer and intra-observer agreement of endoscopic confocal laser endomicroscopy in the assessment of mucosal barrier defects - Gastrointestinal Endoscopy

Smoking increases surgery in Crohn's disease but does not decrease needfor surgery in ulcerative colitis.

#smoking and #ibd. Why you should quit.

http://t.co/StCuFSlrC8

http://onlinelibrary.wiley.com/enhanced/doi/10.1111/apt.13239/ 

Stopping smoking does not increase the need for surgery in UC.http://t.co/LnDeowlJxP

EUS FNA pancreatitic cyst diagnosis

Paper on EUS FNA http://t.co/wry54p3FT4

IBD Asia Pacific Forum, Penang, Malaysia

What a fantastic conference and opportunity to catch up with old friends! 

Smoking ulcerative colitis nicotine review in APT has received a high level of attention online

Our smoking / nicotine review was blogged in Japanese by http://www.watarase.ne.jp. Thank you! 

Great to see the feedback too. 

The Altmetric score is one measure of the quality and quantity of online attention that this article has received. You can read about how Altmetric scores are calculated here.

This article scored 13.22

The context below was calculated when this article was last mentioned on 30th March 2014

Compared to all articles in Alimentary Pharmacology & Therapeutics So far Altmetric has tracked 829 articles from this journal. They typically receive a little less attention than average, with a mean score of 2.9 vs the global average of 4.8. This article has done particularly well, scoring higher than 96% of its peers.

In the 96%ile

Ranks  30th

All articles of a similar age Older articles will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this score to the 213,916 tracked articles that were published within six weeks on either side of this one in any journal. This article has done particularly well, scoring higher than 94% of its contemporaries.

In the 94%ile

Other articles of a similar age in Alimentary Pharmacology & Therapeutics We're also able to compare this article to 136 articles from the same journal and published within six weeks on either side of this one. This article has done very well, scoring higher than 96% of its contemporaries.

In the 96%ile

Ranks  5th

All articles More generally, Altmetric has tracked 2,013,072 articles across all journals so far. Compared to these this article has done particularly well and is in the 94th percentile: it's in the top 10% of all articles ever tracked by Altmetric.

http://onlinelibrary.wiley.com/doi/10.1111/apt.12086/abstract

10.29

ulcerative colitis, smoking and nicotine therapy （Aliment Pharmacol Ther.2012 Oct 16.） （今のところオープンアクセス）

潰瘍性大腸炎が喫煙者に少ないことに着目して行われているニコチンを用いた治療法についての総説。免疫抑制剤や生物学的製剤への使用が制限されるケースの治療のオプションに限られるとした。

Four IBD publications related to pregnancy

Pregnancy-related issues in inflammatory bowel diseases

Four IBD publications related to pregnancy

Allopurinol use in pregnancy in three women with inflammatory bowel disease: safety and outcomes: a case series.

Fazal MW, Doogue MP, Leong RW, Bampton PA, Andrews JM.

BMC Gastroenterol. 2013 Dec 17;13:172. doi: 10.1186/1471-230X-13-172.

PMID:

 

24345189

http://www.ncbi.nlm.nih.gov/pubmed/24345189

Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative views.

Selinger CP, Eaden J, Selby W, Jones DB, Katelaris P, Chapman G, McDondald C, McLaughlin J, Leong RW, Lal S.

J Crohns Colitis. 2013 Jul;7(6):e206-13. doi: 10.1016/j.crohns.2012.09.010

http://www.ncbi.nlm.nih.gov/pubmed/23040449

Pregnancy related issues in inflammatory bowel disease: evidence base and patients' perspective.

Selinger CP, Leong RW, Lal S.

World J Gastroenterol. 2012 Jun 7;18(21):2600-8. doi: 10.3748/wjg.v18.i21.2600. Review.

PMID:

 

22690068

http://cache.oalib.com/cache?m=FCC858EF30C684B2BB9AF77666EB8F5C.html
http://www.ncbi.nlm.nih.gov/pubmed/22690068

Patients' knowledge of pregnancy-related issues in inflammatory bowel disease and validation of a novel assessment tool ('CCPKnow').

Selinger CP, Eaden J, Selby W, Jones DB, Katelaris P, Chapman G, McDonald C, McLaughlin J, Leong RW, Lal S.

Aliment Pharmacol Ther. 2012 Jul;36(1):57-63. doi: 10.1111/j.1365-2036.2012.05130.x. Epub 2012 May 9.

PMID:

 

22568682  

http://www.ncbi.nlm.nih.gov/pubmed/22568682 

Inflammatory bowel diseases lead to disability and moderate-to-severe disability occurs in 1 in 5 patients

Prospective validation study of the International Classification of Functioning, Disability and Health score in Crohn's disease and ulcerative colitis.

Leong RW, Huang T, Ko Y, Jeon A, Chang J, Kohler F, Kariyawasam V.

J Crohns Colitis. 2014 Mar 21. pii: S1873-9946(14)00101-9. 

Good effort to have this published at last. Very topical issue at the moment even at last weekend's AbbVie Symposium. #IBD #Crohn #colitis #disability #ICF #WHO #activity #limitation #clinical

Here is the PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24662396

Twitter @rupertleong

I have completed my webpage www.rupertleong.com.au which contains research information as well as more up to date information on inflammatory bowel diseases and other gastroenterology resources.

My alternate webpage is www.rupertleong.wix.com/rupertleong and is under construction. It has more information regarding endoscopy (gastroscopy and colonoscopy).

I have put a few publications in ResearchGate https://www.researchgate.net/profile/Rupert_Leong

Please also follow me on Twitter - @rupertleong

I hope you find these resources useful!

Most abstracts at Australian Gastroenterology Week, 2011

Had a total of 15 abstracts at AGW in 2011 including 9 as oral presentations and 1 as poster-of-merit.

Chromoendoscopy debate at Australian Gastroenterology Week

Debate on chromoendoscopy in surveillance of patients with chronic IBD colitis at Australian Gastroenterology Week 2011, Brisbane, Australia.

Check out the result of the debate!
http://www.gastroenterologyupdate.com.au/getattachment/45ff6942-e473-408f-96bf-e3986897e3a4/pdf.aspx

Research publications

http://pubget.com/search?q=authors%3A%22rupert+leong%22

Awarded an NHMRC Career Development Fellowship Level 2!

Metabolomics

TRYPTOPHAN METABOLOMICS DIFFERENTIATES IN INFLAMMATORY BOWEL DISEASES.

Bustamante S, Pickford R, Shin S, Luber R, Campbell B, Redmond D, Yau Y, Leong RWL, Wasinger V. Gastroenterology and Liver Services, Concord and Bankstown Hospitals, Sydney; Bioanalytical Mass Spectrometry Facility, The University of New South Wales.

BACKGROUND & AIM: Metabolomics is the physiological study of chemical profiles of specific metabolic processes. The plasma metabolome in IBD has not been previously characterised. Indoleamine 2,3-dioxygenase (IDO) suppresses naïve T cell proliferation by inducing their apoptosis through tryptophan catabolism, which produces the end metabolites quinolinic acid (QA) and picolinic acid (PA). Whether their role in maintaining tolerance is impaired in inflammatory bowel disease (IBD), or if it differentiates Crohn's disease (CD) from ulcerative colitis (UC) and controls, is unknown.

METHODS: Quantitative metabolomics of picolinic and quinolinic acid was performed using gas chromatography/ mass spectrometry (GC/MS) on blinded CD, UC and control plasma. GC/MS was performed on a HP 6890 gas chromatograph interfaced to a mass selective detector. Analysis was performed with the mass spectrometer operating in electron-capture, negative-ion mode, using methane as reagent gas. We have also used a non-targeted approach to explore small molecule metabolites present in IBD plasma to determine if disease state can be linked to physiological changes. Whole metabolome (mass 50 to 1000m/z) was analysed using an Orbitrap MS instrument. SIEVE software (ThermoFisher Scientific) was used to quantitate, while ChemSpider search engine was used to identify the chemical compounds.

RESULTS: Nineteen UC, 16 CD and 9 controls were recruited. QA and PA levels were increased in UC and CD compared to controls with CD reaching statistical significance (P=0.007 for QA and P=0.004 for total metabolite). Both QA and PA increased with CD inflammation (P=0.015 for QA and P=0.006 for total metabolite). Non-targeted metabolomic study revealed a large number of metabolites differentially expressed.

CONCLUSIONS: Plasma metabolomics demonstrated differences in tryptophan metabolism between CD and UC and controls. Additionally, deficiency fatty acid metabolism linked to APO lipoproteins may be a co-factor in peroxisome dysfunction and linked to defects in autophagy in CD.  

AGW Next Week

Two presentations - poster on Metabolomics in IBD and confocal endomicroscopy in IBD.